ALPHA BRIGHT SERUM 20ML
Concentrado intensivo antimanchas
2-3 meses de tratamiento

105,00 IVA incluido

  • Antioxidante, Antipolución
  • Corrector de pigmentación
  • Melasma e hiperpigmentación
  • Piel acnéica, Post acné

Pieles normales y mixtas
Acetyl Glycyl ß-Alanina + 2% Ácido Fítico
+ 8% Ácido L-Ascórbico + Ginkgo Biloba

Sin fragancias, sin conservantes

MODO DE EMPLEO

Aplicar de 3 a 5 gotas una o dos veces al día sobre el conjunto de las zonas afectadas, completar con una protección solar en caso de exposición.

Categoría:

Descripción

Antes / Después

Resultados después de 2 sesiones de Mirconeedling

Imágenes cortesía del Dr. Volkova.

Antes y después de 2 sesiones de microagujas (0.5-0.7mm) y 10 días de ALPHA BRIGHT SERUM, dos veces al día.

HIPERPIGMENTACIÓN POST-ACNÉ

Imágenes cortesía de Dra María Ivonne Arellano Mendoza.

Antes y después de 6 meses de ALPHA BRIGHT SERUM, dos veces al día.

MELASMA = -28%

HIPERPIGMENTACIÓN POST-ACNÉ

Imágenes cortesía de Mayami Clinic Tokio.

Antes y después de 3 meses de ALPHA BRIGHT SERUM, dos veces al día.

Alphascience | Alpha Bright Serum 8ml | Corrector anti manchas

Alphascience | Alpha Bright Serum 8ml | Corrector anti manchas

Alphascience | Alpha Bright Serum 8ml | Corrector anti manchas

Alphascience | Alpha Bright Serum 8ml | Corrector anti manchas

PIGMENTACIÓN POST-DEPILACIÓN

Imágenes cortesía de Brussels Clinic.

Antes y después de 3 semanas de ALPHA BRIGHT SERUM, grandes resultados para la melasma dos veces al día.

Alphascience | Alpha Bright Serum 8ml | Corrector anti manchas

Alphascience | Alpha Bright Serum 8ml | Corrector anti manchas

ARRUGAS Y MANCHAS

Resultados después de 3 meses de usar dos veces al día ALPHA BRIGHT SERUM y Ultra Deep durante junio-agosto del 2018. Disminución de arrugas y manchas marrones.

Alphascience | Alpha Bright Serum 8ml | Corrector anti manchas

Alphascience | Alpha Bright Serum 8ml | Corrector anti manchas

Imágenes cortesía de Bynovitskaya.

Resultados después de usar ALPHA BRIGHT SERUM

Alphascience | Alpha Bright Serum 8ml | Corrector anti manchas

Alphascience | Alpha Bright Serum 8ml | Corrector anti manchas

Antes / Después

Resultados después de 2 sesiones de Mirconeedling

Imágenes cortesía del Dr. Volkova.

Antes y después de 2 sesiones de microagujas (0.5-0.7mm) y 10 días de ALPHA BRIGHT SERUM, dos veces al día.

HIPERPIGMENTACIÓN POST-ACNÉ

Imágenes cortesía de Dra María Ivonne Arellano Mendoza.

Antes y después de 6 meses de ALPHA BRIGHT SERUM, dos veces al día.

MELASMA = -28%

 

HIPERPIGMENTACIÓN POST-ACNÉ

Imágenes cortesía de Mayami Clinic Tokio.

Antes y después de 3 meses de ALPHA BRIGHT SERUM, dos veces al día.

   

 

PIGMENTACIÓN POST-DEPILACIÓN

Imágenes cortesía de Brussels Clinic.

Antes y después de 3 semanas de ALPHA BRIGHT SERUM, grandes resultados para la melasma dos veces al día.

 

ARRUGAS Y MANCHAS

Resultados después de 3 meses de usar dos veces al día ALPHA BRIGHT SERUM y Ultra Deep durante junio-agosto del 2018. Disminución de arrugas y manchas marrones.

 

Imágenes cortesía de Bynovitskaya.

Resultados después de usar ALPHA BRIGHT SERUM

Ficha Técnica

INGREDIENTES CLAVE

Ácido L-Ascórbico Estabilizado, 8%
Antioxidante, estimula la síntesis de colágeno, acelera la renovación celular, limita la transferencia de melanina.

Ácido Fítico, 2%
Antioxidante, neutraliza los contaminantes, hidrata y normaliza el sebo, regula la pigmentación.

Acetyl Glycyl ß-Alanina
Potente péptido antimanchas y aclarador, actúa sobre los 4 niveles de melanogénesis.

Concentrado de Ginkgo Biloba
Antioxidante, actúa sobre la irrigación tisular para mejorar la luminosidad del tono.

INDICACIONES
Manchas pigmentarias de orígenes diversos: léntigos actínicos, léntigos seniles, melasmas. Pigmentaciones post-inflamatorias. Complemento y relevo de procedimientos estéticos (peeling,láser, mesoterapia, etc).

Sin fragancias, sin conservantes.

Modo de Empleo

Aplicar una o dos veces al día sobre el conjunto de las zonas afectadas, completar con una protección solar en caso de exposición.

Archivo Científico

KEY ACTIVE INGREDIENTS

PHYTIC ACID: antioxidant, pollutant scavenger, regulates pigmentation. 

Alphascience | Alpha Bright Serum 20ml | Corrector anti manchas

Alphascience | Alpha Bright Serum 20ml | Corrector anti manchas

Phytic acid is a unique active ingredient to prevent and correct skin aging. Used in high concentration in our serum, it is suitable for skin under oxydative stress, notably in urban environment. In addition, is has an excellent synergic effect with vitamin C.

Phytic acid is found in plant seeds. It serves as the main storage form of phosphorus in the seeds. When seeds sprout, phytic acid is degraded and the phophorus released for use by the young plant.

Protection against pollutants
The latest dermatological clinical studies show that air pollution multiplies undesirable UV radiation effects on skin cells- increasing the photo-actinic da- mages thereby causing wrinkles, brown spots, melasma and skin sagging.1

Phytic Acid has the strong ability to chelate multivalent metal ions, especially zinc, calcium and iron. The binding can result in very insoluble salts that are poorly absorbed. Alternatively, the ability of Phytic Acid to chelate minerals has been reported to have some protective effects, such as decreasing iron-mediated cancer risk and lowering serum cholesterol and triglycerides.

Powerful antioxidant 

Phytic Acid is a powerful natural antioxidant2
It also decreases the rate of lipid peroxidation3. The lipid peroxidation is the process in which free radicals «steal» electrons from the lipids in cell membranes by a free radical chain reaction mechanism resulting in cell damages.

Moisturizing and sebum control 

Use of a 0.5% phytic acid formula regulates the sebum level in both dry skins and oily skins to a value between 100 and 130 μg/cm2, which is the value for a normal skin. This result is due to absorption of phytic acid into the pores after its penetration into stratum corneum and consequently maintaining the appropriate amout of sebum secreted from the sebaceous gland.

 

1 Pollution as a Risk Factor for the Development of Melasma and Other Skin Disorders of

2 Crit Rev Food Sci Nutr. 1995 Nov;35(6):495-508. Phytic acid in health and disease. Zhou JR1, Erdman JW Jr.
3 Phytic Acid Protective Effect Against Beef Round Muscle Lipid Peroxidation. BEOM JUN LEE, DELOY G. HENDRICKS

 

Sebum value for dry skins and oily skins after applying a 0.5% phytic acid lotion for 7 weeks 4

Alphascience | Alpha Bright Serum 20ml | Corrector anti manchas

Alphascience | Alpha Bright Serum 20ml | Corrector anti manchas

Controls excess of melanine to prevent brown spot and lighten the skin 

This result is due to the penetration of phytic acid into basale layer inhibiting the activity of tyrosinase, involved in melanine synthesis.

Decreases the melanine value by 8% in 7 weeks, in vivo study with 20 volunteers5

Alphascience | Alpha Bright Serum 20ml | Corrector anti manchas

Alphascience | Alpha Bright Serum 20ml | Corrector anti manchas

4 Dr Zhong, Soongsil University

5 Dr Zhong, Soongsil University

Phytic Acid properties for skin 

Powerful antioxidant
Chelates heavy metals and iron
Moisturises and regulates sebum production Anti-cancer
Regulates pigmentation
No toxicity

ACETYL GLYCYL ß-ALANINE: POWERFUL ANTI-SPOTS AND LIGHTENING PEPTIDE

Efficacy test on cell culture: effectivness on 4 levels of melanogenesis

Alphascience | Alpha Bright Serum 20ml | Corrector anti manchas

Alphascience | Alpha Bright Serum 20ml | Corrector anti manchas

 

Level 1 – UV activation:  inhibits Stem Cell Factor (SCF) et Endothelin-1 (ET-1)

–  Keratinocyte-derived factors

–  Regulate melanocyte proliferation and differentiation
–  Effective on melanocyte dendrite formation
Alphascience | Alpha Bright Serum 20ml | Corrector anti manchas

Alphascience | Alpha Bright Serum 20ml | Corrector anti manchas

Level 2 – Tyrosinase activation: downregulates MITF mRNA expression by 39%.

Alphascience | Alpha Bright Serum 20ml | Corrector anti manchas

Alphascience | Alpha Bright Serum 20ml | Corrector anti manchas

Level 3: Inhibits tyrosinase level up to 36.5% in protein level

Alphascience | Alpha Bright Serum 20ml | Corrector anti manchas

Alphascience | Alpha Bright Serum 20ml | Corrector anti manchas

Inhibits melanin content up to 45.5%

Alphascience | Alpha Bright Serum 20ml | Corrector anti manchas

Alphascience | Alpha Bright Serum 20ml | Corrector anti manchas

Level 4 – Inhibition of Melanosome Transfer – Phagocytosis

Microsphere-based phagocytosis assay: decrease by 55%

Alphascience | Alpha Bright Serum 20ml | Corrector anti manchas

Alphascience | Alpha Bright Serum 20ml | Corrector anti manchas

In-vivo Age Spot Reducing Study, obny10AwMomAeLnafobro2rmaotnothris

Average spot reduction of 73%

Alphascience | Alpha Bright Serum 20ml | Corrector anti manchas

Alphascience | Alpha Bright Serum 20ml | Corrector anti manchas

Age spot reduction on 2 subjects:

Alphascience | Alpha Bright Serum 20ml | Corrector anti manchas

Alphascience | Alpha Bright Serum 20ml | Corrector anti manchas

Alphascience | Alpha Bright Serum 20ml | Corrector anti manchas

Alphascience | Alpha Bright Serum 20ml | Corrector anti manchas

In-vivo full face lightening study, on 20 women for 2 months

increase in L* value associated with skin lightening by 36%

Alphascience | Alpha Bright Serum 20ml | Corrector anti manchas

Alphascience | Alpha Bright Serum 20ml | Corrector anti manchas

VITAMIN C IN ITS NATURAL FORM (L-ASCORBIC ACID), STABILIZED AT 8% 

Alphascience | Alpha Bright Serum 20ml | Corrector anti manchas

Alphascience | Alpha Bright Serum 20ml | Corrector anti manchas

In its natural form (L- ascorbic acid), Vitamin C is one of the most effective an- ti- aging ingredients but also the most unstable:

–  in surface, L-ascorbic acid stimulates epidermis turnover to increase skin radiance and refine skin texture.
–  At dermal level numerous studies678 proved that L-ascorbic acid boosts collagen synthesis to reduce wrinkles and smooth the skin.
–  It is also one of the most powerful anti-free radicals able to protect from oxidative factors responsible for the premature aging of the skin (UV, stress, pollution.
–  Blocks melanin transfer through a weakening action on dendritis9 The vitamin C is not synthetized by human body and needs external intake.

How do we stabilize L-Ascorbic Acid in high concentration?

Thanks to its control of the chemical characteristics of vitamin C, Alphascience has developed a technology based on a unique associative complex of powerful antioxidants, which ensures the stabilization of highly concentrated L-ascorbic acid.

6 Nusgens BV, Humbert P, Rougier A, et al. Topically applied vitamin C enhances the mRNA level of collagens I and III, their processing enzymes and tissue inhibitor of matrix metalloproteinase 1 in the human dermis J Invest Dermatol 2001 ; 116 : 853-859

7 Stimulation of collagen gene expression by ascorbic acid in cultured human fibroblasts. A role for lipid peroxidation? M Chojkier, K Houglum, J Solis-Herruzo and D A Brenner

8 Ascorbic acid enhances the expression of type 1 and type 4 collagen and SVCT2 in cultured human skin fibroblasts. Y Kishimoto, N Saito, K Kurita, K Shimokado
9 Marta I. Rendon MD, Jorge I. Gaviria MD – Review of Skin-Lightening Agents – Dermatologic Surgery

GINKGO BILOBA – THE TREE OF ETERNITY 

Alphascience | Alpha Bright Serum 20ml | Corrector anti manchas

Alphascience | Alpha Bright Serum 20ml | Corrector anti manchas

It is one of the more ancient tree species that appeared 270 million year ago. Ginkgo Biloba trees were also among the few living things in the area to survive the blast of Hiroshima. Later, scientific studies proved their resistance to mutagenic agents.

Gingko biloba is used in traditional medicine for its multiple properties: antioxidant, and vasoprotective. It improves irrigation of tissues and small blood vessels resistance.

We use Ginkgo Biloba in high concentration in ALPHA BRIGHT SERUM for :

–  its antioxidant effect
–  irrigation of skin tissues to improve skin radiance, notably for smokers and skins suffering from pollution.

ALPHA BRIGHT SERUM – TOLERANCY STUDIES

Performed by independent laboratories:

Cutaneous tolerance study with patch test on 12 subjects during 48 hours – Mean Irritation Index (MII) = 0,14: Alphascience PHYTIC [TC]  SERUM is considered as non-irritant.

Use test under medical control on 21 volunteers

–  Excellente tolerance for 90% of volunteers
–  2 cases of dryness sensation after use, disappeared after applying amoisturizing cream.

Evaluation of the ocular potential irritancy by the neutral red release assay: The product presents not very important cytotoxicity.

Cosmetic product safety report by toxicologist expert
Analysis of the composition of cosmetic products, results of stability testing and challenge testing: the product has no toxic effect found which could affect human health in normal or reasonably foreseeable use

ALPHA BRIGHT SERUM- CLINICAL STUDY

INGREDIENTS : PROPYLENE GLYCOL, ISOPENTYLDIOL, AQUA, ASCORBIC ACID, GINKGO BILOBA LEAF EXTRACT, ETHOXYDIGLYCOL, ACETYL GLYCYL BETA-ALANINE, PEG-8 DIMETHICONE, PHYTIC ACID, AMINOMETHYL PROPANOL, GLYCERETH-26.

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